<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Etty Hary Kusumastuti</style></author><author><style face="normal" font="default" size="100%">Stephanie Natasha Djuanda</style></author><author><style face="normal" font="default" size="100%">Grace Ariani</style></author><author><style face="normal" font="default" size="100%">Gondo Mastutik</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of N-Cadherin and MMP-9 Expression with Regional Nodal Metastasis in Laryngeal Squamous Cell Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Laryngeal cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Metastasis</style></keyword><keyword><style  face="normal" font="default" size="100%">MMP-9</style></keyword><keyword><style  face="normal" font="default" size="100%">N stages</style></keyword><keyword><style  face="normal" font="default" size="100%">N-cadherin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">679-683</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; In laryngeal carcinoma, regional nodal metastasis serves as a significant prognostic factor. A special biomarker is needed to predict the status of nodal metastases. N-cadherin, a binding protein, aids in cell migration and enabling tumor cells to spread to new locations. The involvement of matrix metalloproteinase-9 (MMP-9) in metastasis includes fostering the dissemination of tumor cells from the primary tumor and enhancing tumor cell motility. &lt;strong&gt;Objective:&lt;/strong&gt; This study seeks to explore the distinctions and relationships in N-cadherin and MMP-9 expression among patients with laryngeal squamous cell carcinoma at various N stages. &lt;strong&gt;Methods:&lt;/strong&gt; Employing a cross-sectional approach, this study conducted an analytic observational investigation on formalin-fixed paraffin-embedded patients whose histopathological diagnosis is laryngeal squamous cell carcinoma in the Pathology Laboratory of Dr. Soetomo Regional Public Hospital in 2018–2021. The samples were divided into N stages based on radiological imaging from the CT scan. Immunohistochemistry examinations were performed using N-cadherin and MMP-9 antibodies and scored using the immunoreactive score (IRS), based on percentage and intensity. The differences in expression and correlation between N-cadherin and MMP-9 were analyzed using statistical tests. &lt;strong&gt;Results:&lt;/strong&gt; Statistical insignificance was observed in N-cadherin expression at various N stages (p = 0.099). There were significant differences in MMP-9 expressions at various N stages (p = 0.0006338). There was no correlation between N-cadherin and MMP-9 expression at various N stages in laryngeal squamous cell carcinoma (p = 0.0638, rs = 0.27). &lt;strong&gt;Conclusion:&lt;/strong&gt; In laryngeal squamous cell carcinoma, MMP-9 serves as a predictor for lymph node metastasis, which, if present, deteriorates the patient's prognosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">679</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Etty Hary Kusumastuti&lt;sup&gt;1,2&lt;/sup&gt;*, Stephanie Natasha Djuanda&lt;sup&gt;1,2&lt;/sup&gt;, Grace Ariani&lt;sup&gt;1,2&lt;/sup&gt;, Gondo Mastutik&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Dr Soetomo Academic General Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
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