<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pramudita Riwanti</style></author><author><style face="normal" font="default" size="100%">Intan Kris Prasetyanti</style></author><author><style face="normal" font="default" size="100%">Burhan Ma’arif</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Metabolite Profiling of Compounds from Sargassum polycystum using UPLC-QToF-MS/MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Metabolite profiling</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum polycystum</style></keyword><keyword><style  face="normal" font="default" size="100%">Seaweed</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC-QToF-MS/MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">321-333</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There are many types of seaweed that have high economic value. Brown seaweed (&lt;em&gt;Sargassum polycystum&lt;/em&gt;) can be used as a raw material in the industry and as a medicinal plant. Maintaining the quality of a compound requires an analytical method that can identify the diversity of metabolome profiles. &lt;strong&gt;Objective: &lt;/strong&gt;This investigation seeks to discover the metabolite profile of S. &lt;em&gt;polycystum&lt;/em&gt; from Sumenep, Madura Island, Indonesia, utilizing the UPLC-QToF MS/MS equipment. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extract was further fractioned using n-hexane, ethyl acetate, and water. The metabolite profiling of extract and fractions used the UPLC-QToF-MS/MS instrument. It was produced with SPE and then introduced into the MS Xevo G2-S QToF detector of the ACQUITY UPLC® H-Class System. The findings of the UPLC-QToF-MS/MS analysis were processed with the MassLynx 4.1 software to obtain chromatogram data and m/z spectra of each observed peak, which were then validated using the ChemSpider and MassBank databases. &lt;strong&gt;Results: &lt;/strong&gt;Based on the results of metabolite profiling using UPLC-QToF-MS/MS, the 96 % ethanol extract of S.&lt;em&gt; polycystum&lt;/em&gt; indicated a total of 61 compounds, the n-hexane fraction indicated a total of 55 compounds, the ethyl acetate fraction indicated a total of 67 compounds, and the water fraction indicated a total of 49 compounds. &lt;strong&gt;Conclusion:&lt;/strong&gt; There are 232 compounds in the extract and a fraction of S.&lt;em&gt; polycystum &lt;/em&gt;consisting of 168 known compounds and 64 unknown compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">321</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pramudita Riwanti&lt;sup&gt;1&lt;/sup&gt;, Intan Kris Prasetyanti&lt;sup&gt;2&lt;/sup&gt;, Burhan Ma’arif&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University, Malang, INDONESIA.&lt;/p&gt;
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