<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nafdzu Makhmudatul Muna</style></author><author><style face="normal" font="default" size="100%">Ni Made Mertaniasih</style></author><author><style face="normal" font="default" size="100%">Pepy Dwi Endraswari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation Between the Suitability of Empirical and Definitive Therapies According to Culture Results with the Clinical Outcomes of Patients with Bacteremia Due to Carbapenem- Resistant Acinetobacter baumannii (CRAB) at Dr. Soetomo Tertiary Referral Hosp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acinetobacter baumannii</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteremia</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbapenem-resistant</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical outcomes.</style></keyword><keyword><style  face="normal" font="default" size="100%">Definitive antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Empirical antibiotics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">942-947</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Carbapenem administration is an important therapy for nosocomial infections due to MDRO, especially&lt;em&gt; Acinetobacter baumannii.&lt;/em&gt; The global increase in carbapenem-resistant&lt;em&gt; A. baumannii&lt;/em&gt; (CRAB) that causes this pathogen has significantly threatened public health due to the lack of adequate treatment options due to the very few currently available antimicrobial agents that actively fight CRAB. Antimicrobial resistance is a major negative impact of inappropriate antimicrobial prescribing. Ineffective empiric treatment (initial antibiotic regimen not sensitive to identified pathogens based on &lt;em&gt;in vitro&lt;/em&gt; sensitivity test results) is associated with a higher rate of deaths compared to effective empiric treatment. In this study, we analyzed the correlation between the suitability of empiric and definitive antibiotics and the clinical outcomes of patients with bacteremia due to CRAB treated in the inpatient ward of Dr. Soetomo Tertiary Referral Hospital, Surabaya. There were 227 isolates of bacteremia due to CRAB, consisting of 156 carbapenem-resistant &lt;em&gt;A. baumann&lt;/em&gt;i and 71 carbapenem-sensitive &lt;em&gt;A. baumannii.&lt;/em&gt; There were 88 isolates that met the inclusion and exclusion criteria, and all of them were resistant to ceftriaxone, cefepime, and ciprofloxacin. A total of 29.5% of the isolates were sensitive to cotrimoxazole, 3.4% of the isolates were sensitive to tigecycline, and 2.3% of the isolates were sensitive to amikacin, levofloxacin, and cefoperazone sulbactam. Adequate empirical antibiotics and definitive antibiotics (sensitive based on culture sensitivity test) amounted to 12.5% and 27.3%, respectively. There is no significant correlation between the suitability of empiric and definitive therapies with the patients' clinical outcomes (death and length of stay).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">942</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nafdzu Makhmudatul Muna&lt;sup&gt;1&lt;/sup&gt;, Ni Made Mertaniasih&lt;sup&gt;2,3,4&lt;/sup&gt;,Pepy Dwi Endraswari&lt;sup&gt;2,3,5*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Clinical Microbiology Specialist, Faculty of Medicine, Airlangga University, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Microbiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Microbiology, Dr. Soetomo Academic Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Tropical Diseases, Airlangga University, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Unit of Clinical microbiology, Airlangga University Hospital, Surabaya, Indonesia&lt;/p&gt;
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