<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Numlil Khaira Rusdi</style></author><author><style face="normal" font="default" size="100%">Weri Lia Yuliana</style></author><author><style face="normal" font="default" size="100%">Erni Hernawati Purwaningsih</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subchronic Toxicity of Lunasin Targeted Extract (ET-Lun) from Soybean Seed (Glycine max (L.) Merr.): Perspective from Liver Histopathology, SGOT, and SGPT Levels in Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Lunasin</style></keyword><keyword><style  face="normal" font="default" size="100%">SGOT</style></keyword><keyword><style  face="normal" font="default" size="100%">SGPT</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1384-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Lunasin Targeted Extract (ET-Lun) has a pharmacology effect in inhibiting inflammation by decreasing COX-2 and iNOS expression. ET-Lun could increase apoptosis and decrease dysplasia (p &amp;gt; 0,05). In addition, ET-Lun could decrease EGFR expression in breast cancer rats. The acute toxicity showed ET-Lun has LD50 more than 5000 mg/kg BW and was practically non-toxic. Objective: this study aimed to determine the subchronic toxicity of ET-Lun. &lt;strong&gt;Methods: &lt;/strong&gt;Male and female Sprague Dawley rats (n=40) were divided into 4 groups, the control group and treatment group ET-Lun dose of 250 mg/Kg BW, 500 mg/kg BW, and 750 mg/kg BW. The ET-Lun was administered for 90 days. On the 91st day, the animals were dissected and examined for SGOT-SGPT levels, liver histopathology, and diameter of the central vein.&lt;strong&gt; Results:&lt;/strong&gt; The SGOT-SGPT levels showed no significant difference between the treatment group and the control group (p &amp;gt; 0.05). On microscopic observation, there was no change or damage to the liver of rats in each group. The diameter of the central vein of the rat liver shows no significant difference between the control and treatment groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ET-Lun does not produce adverse effects in liver rats after subchronic treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1384</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Numlil Khaira Rusdi&lt;sup&gt;1,2&lt;/sup&gt;, Weri Lia Yuliana&lt;sup&gt;2&lt;/sup&gt;, Erni Hernawati Purwaningsih&lt;sup&gt;3,4&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;1,4,6,7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA.&lt;/p&gt;
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