<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ariiq Azmi Rofiqi Sulkhan</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author><author><style face="normal" font="default" size="100%">Sutriyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Glycyrrhizin and Sappan Wood Extract on Chemically- Induced Oral Mucosal Ulcer: An in vivo Animal Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">Licorice</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Triamcinolone Acetonide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">909-915</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Stomatitis is the most common oral mucosal lesions characterized by round ulcers with yellow-white color and usually heals up to 14 days. Many recent studies have demonstrated that glycyrrhizin (GL) and &lt;em&gt;C. sappan&lt;/em&gt; extract (CSE) exhibits anti-inflammatory, anti-ulcer and antioxidant action but no study has demonstrated the effect on the oral mucosal ulcer.&lt;strong&gt; Objectives: &lt;/strong&gt;To evaluate the effect of GL and CSE in experimentally chemically induced oral mucosal ulcers using rats. &lt;strong&gt;Methods:&lt;/strong&gt; Male Sprague- Dawley rats were randomly distributed into seven groups: the control group, the comparison group of 0.1% triamcinolone acetonide (TCA), a single treatment group of 3% GL and 3% CSE, combination groups of 3% GL + CSE (1:1, 1:2, 2:1). The oral ulcer model was induced by 15 μL of 50% acetic acid. The clinical healing was evaluated by measuring the ulcer size and body weight from day 0–14 and evaluate the leukocyte number on days 0, 4, 9 and 14. Histological examination was conducted at the end of the treatment. &lt;strong&gt;Results:&lt;/strong&gt; The group of 0.1% TCA and GL:CSE (2:1) showed greater ulcer closure (&amp;gt;80%) and decreased leukocyte number since day 4 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Body weight loss was observed after ulcer initiation and started to increase after day 4 of treatment. While the histological examination showed similar tissue regeneration profile only from the GL:CSE (2:1) group with the healthy oral mucosa. &lt;strong&gt;Conclusion:&lt;/strong&gt; Combination treatment of GL:CSE (2:1) enhanced the closure of oral mucosal ulcer and demonstrate complete tissue regeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">909</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ariiq Azmi Rofiqi Sulkhan&lt;sup&gt;1&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;2&lt;/sup&gt;, Sutriyo&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok West Java 16424, INDONESIA.&lt;/p&gt;
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