<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gunti Gowtham Raja,</style></author><author><style face="normal" font="default" size="100%">Hyma Sara Varghese,</style></author><author><style face="normal" font="default" size="100%">Sarita Kotagiri,</style></author><author><style face="normal" font="default" size="100%">Vrushabendra Swamy B.M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Ehrlich ascites carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Pandanus odoratissimus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">57-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; India is a rich source of medicinal plants and number of plant extracts are used against diseases in various systems of medicine such as ayurveda, unani and siddha where only a few of them were scientifically explored. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study was undertaken to perform dose dependent anti-cancer effect of aqueous and methanolic extracts of &lt;em&gt;P. odoratissimus&lt;/em&gt; roots and leaves whose scientific documentation for anti-tumor agent is lacking despite using traditionally. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The anti-cancer activity of methanolic extract of &lt;em&gt;P. odoratissimus&lt;/em&gt; (MEPO) and aqueous extract of &lt;em&gt;P. odoratissimus&lt;/em&gt; (AEPO) were tested against Ehrlich ascites carcinoma induced liquid tumors in swiss albino mice. The degree of protection was determined by change in body weight (gm), tumour volume (ml), packed cell volume (ml), cell viability (%), hematological parameters (R.B.C, W.B.C and hemoglobin content), mean survival time (MST), % increase in lifespan (% ILS) and histopathological observation of part of peritoneal layer.&lt;strong&gt; Results:&lt;/strong&gt; The treatment with AEPO 400 mg/kg, p.o. in EAC treated mice reduced tumor volume, packed cell volume, body weight, cell viability and improved all hematological parameters, mean survival time and life span. Histopathological changes showed degenerative changes of tumor cells in peritoneal layer. The anti-cancer effects of AEPO 400 mg/kg, p.o. are equally more with that of the standard drug cisplatin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggested that aqueous extract of roots and leaves of &lt;em&gt;P. odoratissimus&lt;/em&gt; possess &lt;em&gt;in vivo&lt;/em&gt; anti-cancer activity comparable to cisplatin and this study scientifically validated the traditional use of this plant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Anticancer, &lt;em&gt;Pandanus odoratissimus&lt;/em&gt;, Ehrlich ascites carcinoma.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gunti Gowtham Raj&lt;sup&gt;a&lt;/sup&gt;, Hyma Sara Varghese&lt;sup&gt;b&lt;/sup&gt;, Sarita Kotagiri&lt;sup&gt;c&lt;/sup&gt; and Vrushabendra Swamy B.M&lt;sup&gt;c&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department of Pharmacology, Gautham College of Pharmacy, Sultanpalya, Bangalore, Karnataka &amp;ndash; 560 032, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Pharmacology, Hillside College of Pharmacy and Research centre, Raghuvanahalli, Bangalore, Karnataka &amp;ndash; 560 062, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Pharmacology, East point College of Pharmacy, Bangalore,Karnataka &amp;ndash; 560 049, India.&lt;/p&gt;</style></auth-address></record></records></xml>