<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">V. R. Patil</style></author><author><style face="normal" font="default" size="100%">V. M. Thakare</style></author><author><style face="normal" font="default" size="100%">V.S. Joshi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory Activity of Atalantia monophylla DC. roots</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atalantia monophylla</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell-mediated immune response</style></keyword><keyword><style  face="normal" font="default" size="100%">Humoral immune response.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">37-43</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The objective of the present study was to evaluate the immunomodulatory activity of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of&lt;em&gt; Atalantia monophylla&lt;/em&gt;, were administered orally, in the doses of 10 mg/kg and 30 mg/kg, to evaluate the immunomodulatory activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Methanolic fraction showed most significant effect when compared with control group, in the dose of 30 mg/kg, in the&lt;em&gt; E.Coli&lt;/em&gt; induced abdominal sepsis and Carbon Clearence Test as models for non-specific immune response. In the models of the Specific immune response, cell mediated immune response to SRBC - delayed type of hypersensitivity (DTH) the methanolic fraction in the dose 30 mg/kg, when compared with control group, showed most significant effect on decrease in footpad edema after treatment. &lt;strong&gt;Results:&lt;/strong&gt; Humoral immune response was assessed by Sheep erythrocyte agglutination test, in which the Methanolic fraction of&lt;em&gt; Atalantia monophylla &lt;/em&gt;in the dose of 30 mg/kg showed most significant (p&amp;lt;0.05) increase in antibody titer after treatment when compared with control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present investigation reports that the Methanolic fraction of the ethanolic extract of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;, in the dose of 30 mg/kg showed most significant immunomodulatory activity.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Atalantia monophylla&lt;/em&gt;, Immunomodulatory, Phagocytosis, Cell-mediated immune response, Humoral immune response.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">V. R. Patil, V. M. Thakare, V.S. Joshi</style></custom1><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;V. R. Patil, V. M. Thakare, V.S. Joshi&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy, TVES&amp;rsquo;s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur &amp;ndash; 425503, Dist- Jalgaon, Maharashtra, India&lt;/p&gt;</style></auth-address></record></records></xml>