<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaik Aminabee</style></author><author><style face="normal" font="default" size="100%">Atmakuri Lakshmana Rao</style></author><author><style face="normal" font="default" size="100%">Maram Chinna Eswaraiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albino rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Michelia nilagirica</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">228-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt;Michelia nilagirica&lt;/em&gt; belonging to the family &lt;em&gt;Mangoliaceae&lt;/em&gt; is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. &lt;strong&gt;Objective:&lt;/strong&gt; Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. &lt;strong&gt;Materials &amp;amp; Methods: &lt;/strong&gt;Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. &lt;strong&gt;Results: &lt;/strong&gt;The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) &amp;amp; Serum bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Albino rats, Hepatoprotective, &lt;em&gt;Michelia nilagirica&lt;/em&gt;, Paracetamol, Screening.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">228</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shaik Aminabee&lt;sup&gt;1&lt;/sup&gt;, Atmakuri Lakshmana Rao&lt;sup&gt;*1&lt;/sup&gt; and Maram Chinna Eswaraiah&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>