<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Zarina Abd Wahab</style></author><author><style face="normal" font="default" size="100%">Aziah Azizul</style></author><author><style face="normal" font="default" size="100%">Norhidayah Badya</style></author><author><style face="normal" font="default" size="100%">Nazlina Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">(3-(4</style></keyword><keyword><style  face="normal" font="default" size="100%">5-dimethylthiazol-2-yl)-2</style></keyword><keyword><style  face="normal" font="default" size="100%">5-diphenyltetrazolium bromide); virucidal.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cynometra cauliflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Herpes simplex virus type 1</style></keyword><keyword><style  face="normal" font="default" size="100%">plaque reduction assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">752-757</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cynometra cauliflora&lt;/em&gt; is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. &lt;strong&gt;Objectives:&lt;/strong&gt; In this study, &lt;em&gt;Cynometra cauliflora &lt;/em&gt;methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaves of &lt;em&gt;C. cauliflora&lt;/em&gt; plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of&lt;em&gt; C. cauliflora&lt;/em&gt; extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. &lt;strong&gt;Results:&lt;/strong&gt; The value of cytotoxic concentration, CC&lt;sub&gt;50&lt;/sub&gt; of&lt;em&gt; C. cauliflora&lt;/em&gt; extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. &lt;em&gt;C. cauliflora &lt;/em&gt;extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study provides important novel insights on the phytomedicinal properties of &lt;em&gt;C. cauliflora&lt;/em&gt; extracts on HSV-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">752</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Noor Zarina Abd Wahab&lt;sup&gt;1,&lt;/sup&gt;*, Aziah Azizul1, Norhidayah Badya&lt;sup&gt;2&lt;/sup&gt;, Nazlina Ibrahim&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Terengganu, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan, Bangi, MALAYSIA.&lt;/p&gt;
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