<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sachin Neekhra</style></author><author><style face="normal" font="default" size="100%">Himani Awasthi</style></author><author><style face="normal" font="default" size="100%">Dharmchand Prasad Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Beneficial Effects of Sambucus nigra in Chronic Stress-Induced Neurobehavioral and Biochemical Perturbation in Rodents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Active avoidance response</style></keyword><keyword><style  face="normal" font="default" size="100%">Cold immobilization</style></keyword><keyword><style  face="normal" font="default" size="100%">Footshock induced stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid profiles</style></keyword><keyword><style  face="normal" font="default" size="100%">Sambucus nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Sexual behaviour</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">155-161</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Stress is the causative factor for various diseases and disorders faced by the majority of the diseased population. The leaves of &lt;em&gt;Sambucus nigra&lt;/em&gt; (&lt;em&gt;S. nigra&lt;/em&gt;) are attributed to neuropharmacological properties as per literature. Considering the above, the &lt;em&gt;S. nigra &lt;/em&gt;hydroalcoholic extract was tested for adaptogenic activity in animals.&lt;strong&gt; Objective: &lt;/strong&gt;The study deals with the evaluation of &lt;em&gt;S. nigra &lt;/em&gt;hydroalcoholic extract for adaptogenic activity using cold immobilization and footshock induced stress. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The &lt;em&gt;S. nigra &lt;/em&gt;hydroalcoholic extract (200 and 400 mg/kg) was administered to treatment groups 1 hour before footshock for 14 consecutive days and cold immobilization stress for 10 consecutive days, respectively. The current work was carrying out to investigate the adaptogenic activity of&lt;em&gt; S. nigra&lt;/em&gt; against footshock stress induced perturbations in behaviour (sexual behaviour, depression, and cognitive dysfunction). Suppressed male sexual behaviour, percentage active avoidance response and duration of immobility in footshock stress were used as the stress indices. Additionally, liver function (SGOT, SGPT, and ALP), lipid profiles (TC, TG, HDL, LDL, and VLDL) and differential leukocytes counts (neutrophils, eosinophils, lymphocyte, and monocyte) in cold immobilization stress were assessed in terms of stress indices. Diazepam (1 mg/kg) was served as the standard adaptogenic agent as per literature review for comparison.&lt;strong&gt; Results:&lt;/strong&gt; All these chronic stress-induced perturbations were reversed, dose-dependently by &lt;em&gt;S. nigra&lt;/em&gt; (2000 and 400 mg/kg) and diazepam (1 mg/kg). The dose group 400 mg/kg p.o. of &lt;em&gt;S. nigra&lt;/em&gt; hydroalcoholic extract for adaptogenic activity in cold immobilization and footshock induced stress method showed significant variation (P&amp;lt; 0.1) when is compared with the stress control group.&lt;strong&gt; Conclusion:&lt;/strong&gt;&lt;em&gt;&lt;strong&gt; &lt;/strong&gt;S. nigra&lt;/em&gt; hydroalcoholic extract showed significant adaptogenic activity was indicated by qualitatively results comparable to diazepam, against a range of biochemical and behavioural perturbations induced by chronic stress.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sachin Neekhra&lt;sup&gt;1&lt;/sup&gt;, Himani Awasthi&lt;sup&gt;1,&lt;/sup&gt;*, Dharmchand Prasad Singh&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Amity Institutes of Pharmacy, Amity University Uttar Pradesh, Near Malhaur Station, Gomati Nagar Extension, Lucknow (U.P.) – 226010, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;College of Pharmacy, SR Group of Institutions, Ambabai, Jhansi (U.P.) – 284002, INDIA.&lt;/p&gt;
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