<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kesaktian Manurung</style></author><author><style face="normal" font="default" size="100%">Delmi Sulastri</style></author><author><style face="normal" font="default" size="100%">Nasrul Zubir</style></author><author><style face="normal" font="default" size="100%">Syafruddin Ilyas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Anticancer Activity and in vitro Antioxidant of Flavonoids in Plectranthus amboinicus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1573-1577</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng is a plant that has a high flavonoid content. The leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng contain many flavonoids Chrysoeriol, Cirsimaritin, Eriodictyol, Luteolin, Rutin, Salvigenin, Thymoquinone, Quercetin, Apigenin, and 5-O-Methyl-Luteolin. &lt;strong&gt;Objectives:&lt;/strong&gt; To determine the antioxidant activity and anticancer activity of flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng. &lt;strong&gt;Methods: &lt;/strong&gt;Anticancer activity testing was carried out by in silico against several cancer receptors and antioxidant activity testing was carried out by in vitro using the 1,1-Diphenyl-2-Picryhydrazil method. The results showed that the flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng have similar anticancer activity to the reference molecule at the P-Glycoprotein-1, Cyclin Dependent Kinase-2, and Phosphoinositide-3-Kinase receptors, as well as better anticancer activity than the reference molecule for the Cyclooxygenase-2 and Phosphoenolpyruvate Carboxykinase receptors. &lt;strong&gt;Results: &lt;/strong&gt;The antioxidant activity of the extract gave an Inhibitory Concentration 50% value of 9.77 μg/mL, the flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng gave an Inhibitory Concentration 50% value that lower than the extract, which ranged from 6.92 μg/mL to 8.50 μg/mL. Flavonoids in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng anticancer activity by in silico molecular docking and antioxidant activity by in vitro 1,1-Diphenyl-2-Picryhydrazil method.&lt;strong&gt; Conclusions: &lt;/strong&gt;All the flavonoid compounds contained in the ethanolic extract of&lt;em&gt; Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng leaves exhibit very strong anti-cancer and antioxidant activity, which results in ethanolic extract of&lt;em&gt; Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng leaves have very strong antioxidant activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1573</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kesaktian Manurung&lt;sup&gt;1,2&lt;/sup&gt;, Delmi Sulastri&lt;sup&gt;3,&lt;/sup&gt;*, Nasrul Zubir&lt;sup&gt;3&lt;/sup&gt;, Syafruddin Ilyas&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Sciences, Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang, Sumatera Barat 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy and Health Sciences, Sari Mutiara Indonesia University, Helvetia Tengah, Medan Helvetia, Medan, Sumatera Utara 20124, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang, Sumatera Barat 25176, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Mathematic and Natural Sciences, Sumatera Utara University, Padang Bulan, Medan Baru, Medan, Sumatera Utara 20155, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>