<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Badarinath Druvarao Kulkarni</style></author><author><style face="normal" font="default" size="100%">Samim Sultana</style></author><author><style face="normal" font="default" size="100%">Mayuri Bora</style></author><author><style face="normal" font="default" size="100%">Ishita Dutta</style></author><author><style face="normal" font="default" size="100%">Padmaa Milaap Paarakh</style></author><author><style face="normal" font="default" size="100%">Vedamurthy Ankala Basappa.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity Studies of Zn (Zinc) Nanoparticles Synthesized from Abutilon indicum L. against Human Cervical Cancer (HeLa) Cell Lines.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abutilon indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Zn nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">127-131</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The Zn nanoparticles synthesized from the plant sources are ecofriendly and are potent anticancer agents. &lt;strong&gt;Objective&lt;/strong&gt;: The objective of the present work was to evaluate &lt;em&gt;In vitr&lt;/em&gt;o cytotoxic activity of Zn nanoparticles green synthezised from &lt;em&gt;Abutilon indicu&lt;/em&gt;m extract against HeLa cell lines (cervical cancer). &lt;strong&gt;Methods:&lt;/strong&gt; The aqueous extract is prepared by cold extraction (maceration) using water as a solvent. Phytochemical analysis was done by using the standard procedures. Aqueous extract of &lt;em&gt;A. indicum&lt;/em&gt; was used for synthesis of Zn nanoparticles. The nanoparticles were characterized by UV-Visible spectrometry and Scanning electron microscopy (SEM) techniques. &lt;em&gt;In vitro&lt;/em&gt; cytotoxicity studies of Zn nanoparticles were done by MTT assay using HeLa cell lines. &lt;strong&gt;Results:&lt;/strong&gt; The preliminary phytochemical results revealed that the aqueous extract of &lt;em&gt;A. indicum&lt;/em&gt; contains broad spectrum of secondary metabolites like Tannins, Saponins, Glycosides, Flavonoids, Anthroquinones, Terpenoids and Steroids. The U.V spectrophotometeric analysis of Zn nanoparticles displayed maximum absorption at 270 nm and scanning electron microscopic studies showed that the nanoparticles size ranges from 50-500 nm. The MTT assay results revealed that the of Zn nanoparticles exhibits potent cytotoxicity against HeLa cell lines with IC&lt;sub&gt;50&lt;/sub&gt; value of 45.82 &amp;mu;g/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus the present study concludes that Zn nanoparticles can be used as a potent drug in alternative therapy for treating the cervical cancer patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">127</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Badarinath Druvarao Kulkarni&lt;sup&gt;1&lt;/sup&gt;, Samim Sultana&lt;sup&gt;2&lt;/sup&gt;, Mayuri Bora&lt;sup&gt;2&lt;/sup&gt;, Ishita Dutta&lt;sup&gt;2&lt;/sup&gt;, Padmaa Milaap Paarakh&lt;sup&gt;3&lt;/sup&gt;, Vedamurthy Ankala Basappa&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology and Microbiology, Karnatak University, Dharwad, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, The Oxford College of Science, Bangalore, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, The Oxford College of Pharmacy, Bangalore-560 068, INDIA.&lt;/p&gt;
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