<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vishnu Priya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Janardhana Papayya Balakrishna</style></author><author><style face="normal" font="default" size="100%">Gayathri Rengasamy</style></author><author><style face="normal" font="default" size="100%">Surapaneni Krishna Mohan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemopreventive Action of Garcinia Mangostana Linn. on Hepatic Carcinoma by Modulating Ornithine Decarboxylase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diethyl nitrosamine</style></keyword><keyword><style  face="normal" font="default" size="100%">G. Mangostana extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocellularcarcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Ornithine decarboxylase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1383-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ornithine decarboxylase and alpha -L- fucosidase over-expression is associated with advanced hepatocellular carcinoma (HCC) development. The objective of this study was to elucidate the action of &lt;em&gt;Garcinia Mangostana &lt;/em&gt;fruit extract (GME) on these overexpressed enzymes and apoptotic proteins in diethyl nitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats. The cancer was induced using DEN to the experimental rats and treated with GME (400 mg/ kg) to find its anticancer property. The lysosomal enzymes such as alpha-L-fucosidase, beta- D-glucosidase, ornithine decarboxylase activity (ODC), apoptotic and antiapoptotic proteins such as Bcl-2, Bax and Bcl-xl and H&lt;sup&gt;3&lt;/sup&gt; thymidine incorporation assay were done to prove GME’s chemo preventive property. DEN induction caused significant increase in the activities of ornithine decarboxylase; lysosomal enzymes and increased cell proliferation with decreased apoptosis were observed. In contrast, the groups with GME treated rat’s elicited significant (&lt;em&gt;P&lt;/em&gt; &amp;lt; 0.001) reduction in ornithine decarboxylase, lysosomal enzymes and decreased cell proliferation with increased apoptosis. GME has effective chemo preventive property and can serve as an anticarcinogenic therapeutic drug against hepatocellular carcinoma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1383</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vishnu Priya Veeraraghavan&lt;sup&gt;1,&lt;/sup&gt;*, Sardar Hussain&lt;sup&gt;2&lt;/sup&gt;, Janardhana Papayya Balakrishna&lt;sup&gt;3&lt;/sup&gt;, Gayathri Rengasamy&lt;sup&gt;4&lt;/sup&gt;, Surapaneni Krishna Mohan&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Government science College, chitradurga-577501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor,10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai – 600 123, Tamil Nadu, INDIA.&lt;/p&gt;
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