<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">PS Dhivya</style></author><author><style face="normal" font="default" size="100%">P Selvamani</style></author><author><style face="normal" font="default" size="100%">S Latha</style></author><author><style face="normal" font="default" size="100%">Vasudevan Mani</style></author><author><style face="normal" font="default" size="100%">Nur Syamimi Mohd Azahan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Evaluation of Acetylcholinesterase Inhibitory and Neuroprotective Activity in Commiphora species: A Comparative Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Aβ25-35</style></keyword><keyword><style  face="normal" font="default" size="100%">Commiphiora pubescens</style></keyword><keyword><style  face="normal" font="default" size="100%">Commiphora berryi</style></keyword><keyword><style  face="normal" font="default" size="100%">Commiphora caudata</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">SH-SY5Y Cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">202</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1223-1231</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Herbal medicines are widely used in the therapeutic intervention that could delay the onset of Neurodegenerative diseases like, Alzheimer’s disease. Despite intensive advancements in the field of research currently available therapeutic strategies are often limited due to their adverse effects. Hence there is a need for the search for novel compounds for effective medications to treat neurocognitive deficits. &lt;strong&gt;Objective: &lt;/strong&gt;The present study focused on acetylcholinesterase inhibitory and neuroprotective activity of &lt;em&gt;Commiphora species&lt;/em&gt; plant for their possible use in Alzheimer’s disease. &lt;strong&gt;Methods:&lt;/strong&gt; Phytochemical screening, TLC bioautographic and colourimetric assay was performed to quantify their acetylcholinesterase inhibitory activity of ethanolic extracts of the &lt;em&gt;Commiphora species&lt;/em&gt;. The MTT assay was carried to evaluate the neuroprotective effect against the Aβ-induced cytotoxicity in SHSY5Y cell lines. &lt;strong&gt;Results: &lt;/strong&gt;The bark of &lt;em&gt;Commiphora berryi&lt;/em&gt;, leaves of &lt;em&gt;Commiphora caudata&lt;/em&gt; and &lt;em&gt;Commiphora pubescens&lt;/em&gt; were found abundant in flavonoids, glycosides, steroids and terpenoids. Further, the ethanol extract of &lt;em&gt;Commiphora berryi&lt;/em&gt; (65.48% ± 0.10) showed the highest acetylcholinesterase inhibitory activity. The Aβ&lt;sub&gt;25-35&lt;/sub&gt; induced cell damage was as evidenced at a concentration of 20μM. The neuroprotective effect of the ethanol extracts was examined in neurodegenerative cells induced by Aβ&lt;sub&gt;25-35&lt;/sub&gt;. On pretreatment with plant extracts, significant improvement in cell viability was observed as 63.42 ± 2.02% (25μg/ml) for &lt;em&gt;Commiphora berryi&lt;/em&gt;. The maximum percentage of &lt;em&gt;in-vitro&lt;/em&gt; AChE inhibition and neuroprotective effect was effective in the ethanol bark extract of &lt;em&gt;Commiphora berryi&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results are very rousing to continue the screening of more unexplored plant species could be used for the development of novel bioactive compounds to treat the many diseases, especially for Alzheimer's disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;PS Dhivya&lt;sup&gt;1,&lt;/sup&gt;*, P Selvamani&lt;sup&gt;2&lt;/sup&gt;, S Latha&lt;sup&gt;3&lt;/sup&gt;, Vasudevan Mani&lt;sup&gt;4&lt;/sup&gt;, Nur Syamimi Mohd Azahan&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Technology, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy, UniversitiTeknologi MARA (UiTM), 42300 Bandar PuncakAlam, Selangor, MALAYSIA.&lt;/p&gt;
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