<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Omar Mohamed Mohamed Sabry</style></author><author><style face="normal" font="default" size="100%">Abeer Mohamed El Sayed</style></author><author><style face="normal" font="default" size="100%">Salmin Khalid Alshalmani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC/MS Analysis and Potential Cytotoxic Activity of Haplophyllum tuberculatum Essential Oils Against Lung and Liver Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplophyllum tuberculatum</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung cancer.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">66-69</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Haplophyllum&lt;/em&gt;&lt;em&gt; tuberculatum&lt;/em&gt; is a plant belongs to family rutacee. It is rich in volatile oils, fixed oils, alkaloids, and furanocoumarins. It is well known for the huge number of folkloric uses in middle east. &amp;nbsp;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study is to establish the chemical composition of the essential oils of Libyan &lt;em&gt;H. tuberculatum&lt;/em&gt; and to investigate their cytotoxic potentialities. &lt;strong&gt;Materials and Methods&lt;/strong&gt;&lt;strong&gt;:&lt;/strong&gt; The essential oils of the aerial parts and flowers of &lt;em&gt;H. tuberculatum&lt;/em&gt; growing in Libya were prepared by hydrodistillation. GC/MS analyses were performed on a Shimaduz capillary gas chromatograph (GC 17A ver.3) instrument directly coupled to mass spectrometer-MS QP5050A. Oil A and F of &lt;em&gt;H. tuberculatum&lt;/em&gt; at different concentrations (0-50 &amp;micro;g/ml) in DMSO were tested for cytotoxicity against human tumor cell lines. &lt;strong&gt;Results:&lt;/strong&gt; Oil yield was found 0.4 and 1.5 (v/w %) on dry weight basis respectively. GC/MS analysis resulted in identification of total 35 compounds. 15 compounds&amp;nbsp; were common to both oils. oil A of &lt;em&gt;H. tuberculatum &lt;/em&gt;exhibited antitumor activities against&lt;em&gt;.&lt;/em&gt; liver carcinoma cell line (HEPG2) and lung carcinoma cell line (H1299) 4.7 &amp;micro;g/ml and 4.1 &amp;micro;g/ml.&lt;strong&gt; Conclusion:&lt;/strong&gt; Essential oil of the aerial parts of &lt;em&gt;H. tuberculatum&lt;/em&gt; is potentially active against lung (H-1299), and liver (HEPG2) carcinoma cell lines. The observed cytotoxic, activities can be attributed to the dominance of &amp;alpha; and &amp;gamma;-terpinene in this oil.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">66</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Omar Mohamed Mohamed Sabry&lt;sup&gt;1,2*&lt;/sup&gt;, Abeer Mohamed El Sayed&lt;sup&gt;1&lt;/sup&gt;and Salmin Khalid Alshalmani&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, 11562, Cairo, Egypt.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Benghazi University, Benghazi, Libya.&lt;/p&gt;</style></auth-address></record></records></xml>