<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shravan Kumar Paswan</style></author><author><style face="normal" font="default" size="100%">Sajal Srivastava</style></author><author><style face="normal" font="default" size="100%">Chandana Venkateswara Rao</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of Ethanolic Extract of Selaginella Bryopteris on Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Selaginellabryopteris</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Excision Model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">335-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The objective of the present study was to determine wound healing activity of ethanolic extract of&lt;em&gt; Selaginella bryopteris &lt;/em&gt;on rats. The whole plant of &lt;em&gt;S. bryopteris&lt;/em&gt; Linn. was collected from Andhra Pradesh, India and extraction was done using ethanol. GC-MS analysis was performed to determine active metabolites present in the extract followed by determination of total phenolic and flavonoid contents. &lt;em&gt;In vivo&lt;/em&gt; wound healing activity of ethanolic extract was evaluated using excision wound model. The extract was applied topically on animals by preparing ointment in two concentrations (5% and 10%) where soframycin (10%) was taken as positive control. Antioxidant activity of &lt;em&gt;S. bryopteris &lt;/em&gt;extract was observed by measuring oxidative enzymatic levels i.e. Superoxide dismutase (SOD), Catalase (CAT), reduced Glutathione (GSH) and lipid peroxidation (LPO) in animal tissues. Histopathological studies of excised skin were carried out after the experimental period. The contraction rate of the wound was higher and dose-dependent in rats treated with 5% and 10 % ointment of extract in comparison to untreated control group. The drug treated groups showed recovery phase and the percentage of healing was more in 10% at the end of experimental period. Results exhibited sufficient insights on the healing process with normal recovery stages and restored oxidative enzymatic levels. Histopathological findings provided additional positive results; the dermis with proliferating capillaries and skeletal muscle were replaced by cellular fibrous tissue and collagen fibers. Overall, the results showed that ethanolic extract of &lt;em&gt;S.bryopteris&lt;/em&gt; was an interesting traditional agent that possess significant wound healing activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">335</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shravan Kumar Paswan&lt;sup&gt;1,2,&lt;/sup&gt;*, Sajal Srivastava&lt;sup&gt;2&lt;/sup&gt;, Chandana Venkateswara Rao&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Division, CSIRNational Botanical Research Institute, Lucknow-226001, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Amity Institute of Pharmacy, Amity University, Gomati Nagar, Lucknow- 226010, Uttar Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record></records></xml>