<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferubko EV</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correction of Toxic Liver Damage with a Multicomponent Herbal Extract in an Animal Experiment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Choleretic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental hepatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Multicomponent extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">168-172</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Digestive diseases constitute a significant part in the overall structure of human diseases. Herbal cholagogues are indicated for a treatment of chronic liver, gall bladder, and bile ducts diseases. The aim of the work is to determine the choleretic effect of a new multicomponent plant extract.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Multicomponent plant extract was obtained from the following types of plant materials: 300 g of immortelle flowers (&lt;em&gt;Helichrysum arenarium&lt;/em&gt; L.), 100 g of tansy flowers (&lt;em&gt;Tanacetum vulgare&lt;/em&gt; L.), 100 g of rose fruits (&lt;em&gt;Rosa &lt;/em&gt;sp.), 100 g of leaves of common nettle (&lt;em&gt;Urtica dioica &lt;/em&gt;L.), 50 g of mint leaves (&lt;em&gt;Mentha piperita&lt;/em&gt; L.), 50 g of licorice roots (&lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; L.). The extract was standardized by the total flavonoid content. It was calculated and expressed in terms of luteolin and isosalipurposide standards (total flavonoids content: not less than 4% and 15% respectively). The animal experiments being done in 80 nonlinear male rats with initial body weight 180-200 g. In order to study a choleretic effect of multicomponent herbal extract, naive rats recieved the single experimental dose of 250 mg/kg. Pharmacotherapeutic activity was studied in white rats with CCl&lt;sub&gt;4&lt;/sub&gt;-induced hepatitis. &lt;strong&gt;Results: &lt;/strong&gt;Studies indicate a pronounced choleretic effect of the studied plant extract, that is comparable with the effect of “Allochol” in intact rats experiments. The course administration of a per os (peroral) multicomponent plant extract in a dose of 250 mg/kg to white non-linear rats with tetrachloromethane liver damage has a choleretic effect: it increases the rate of bile secretion, stimulates the synthesis and secretion of cholates with bile, and also the excretion of cholesterol and bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained research results argue the feasibility of using a multicomponent plant extract containing biologically active substances of phenolic nature in the prevention and comprehensive treatment of liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">168</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ferubko EV&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Rendyuk TD&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;
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