TY - JOUR T1 - Bio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials JF - Pharmacognosy Journal Y1 - 2016 A1 - Tchimene Kenne Michel A1 - Anaga Arua Ottoh A1 - Ugwoke Christopher Emeka Chukwunonye A1 - Ezugwu Christopher Obodoike A1 - Okunji Christopher A1 - Iwu Maurice Mmaduakolam KW - Anti-inflammatory KW - Carrageenan KW - Garcinia kola KW - Paw edema KW - Wistar rats. AB -

Objective: The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of Garcinia kola seeds. Materials and Method: To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of G. kola carrageenan-induced edema model in wistar albino rats was used. Results: Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. Conclusion: Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.

VL - 8 IS - 1 ER -