TY - JOUR T1 - Effect of Trigonella foenum gracecum (fenugreek) Seed Extract in Experimentally Induced Gastric Ulcer in Wistar Rats JF - Pharmacognosy Journal Y1 - 2018 A1 - shreelakshmidevi singaravelu A1 - Jaikumar Sankarapillai A1 - Abilash Sasidaran Chandrakumari A1 - Pammy Sinha KW - Fenugreek KW - Gastro-protection KW - Indomethacin KW - seed-extract KW - Ulcer inhibition AB -

Background: Trigonella foenum graceum (Fenugreek) seeds are commonly used in India as traditional medicine for Diabetes, Dysmenorrhea, lactation and arthritis. The gastro-protective role of Fenugreek seeds are yet to be explored. Objectives: To evaluate the effect of Fenugreek seed extract in Indomethacin induced gastric ulcer models. Materials and Methods: Albino wistar rats were divided into five groups with eight animals in each. Gastric ulcer was induced using Indomethacin 20 mg/Kg. Fenugreek at dose of 200mg/Kg and 400mg/Kg was administered to group III, IV and group V received Rantidine 30mg/Kg. Ulcer index, volume of gastric juice and acidity was estimated. To study the anti-oxidant property the level of catalase, SOD, GST and T. Bars were done. Results: Fenugreek treated group III showed a significant decrease in ulcer index, volume of gastric juice and acidity when compared to control positive group II. Oxidative enzyme study indicated a significant increase in Catalase, SOD and GSH value in treated group when compared with control positive group II and significant decrease in T. Bars value in treated group. Conclusion: Fenugreek seed extract has both gastro-protective and Anti-oxidant property.

VL - 10 IS - 6 ER -