TY - JOUR T1 - Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area. JF - Pharmacognosy Journal Y1 - 2017 A1 - Daniel Rodrigo Cavalcante de Araújo A1 - Luís Cláudio Nascimento da Silva A1 - Wolfgang Harand A1 - Júlia Morais Fernandes A1 - Thaciane da Cunha Soares A1 - Silvana Maria Zucolotto Langassner A1 - Raquel Brandt Giordani A1 - Rafael Matos Ximenes A1 - Alexandre Gomes da Silva A1 - Márcia Vanusa da Silva A1 - Maria Tereza dos Santos Correia KW - Antimicrobial agents KW - Medicinal plants KW - Natural products KW - Semi arid area AB -

Background: Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. Objective: This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of A. colubrina. Material and Methods: Samples were collected in Catimbau National Park (Buíque, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. Results: All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (ρ: -0.99), EALE (ρ: -0.81), CHFE (ρ: -0.81), EAFE (ρ: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. Conclusion: Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. colubrina, however these extracts showed more chemical diversity during dry months.

VL - 9 UR - /files/PJ-9-4/10.5530pj.2017.4.73 IS - 4 ER -