01858nas a2200253 4500008004100000245010800041210006900149260001200218300001000230490000600240520105900246653002201305653001601327653001801343653001401361653001701375100002801392700002301420700003601443700003301479700002401512700003001536856003801566 2016 eng d00aBio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials0 aBioFlavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds c09/2015 a56-580 v83 a
Objective: The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of Garcinia kola seeds. Materials and Method: To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of G. kola carrageenan-induced edema model in wistar albino rats was used. Results: Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. Conclusion: Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.
10aAnti-inflammatory10aCarrageenan10aGarcinia kola10aPaw edema10aWistar rats.1 aMichel, Tchimene, Kenne1 aOttoh, Anaga, Arua1 aChukwunonye, Ugwoke, Christophe1 aObodoike, Ezugwu, Christophe1 aChristopher, Okunji1 aMmaduakolam, Iwu, Maurice uhttps://www.phcogj.com/article/98