02707nas a2200265 4500008004100000245017700041210006900218260001800287300001200305490000700317520175300324653001602077653002602093653003002119653002102149653002302170653002502193100003202218700003802250700003102288700003002319700002502349700002802374856003902402 2019 eng d00aProtective Effect of Terminalia catappa Leaves and Terminalia chebula Fruits on the Enzymatic and Non-enzymatic Anti-oxidant Levels in the Doxorubicin Induced Toxicity Rats0 aProtective Effect of Terminalia catappa Leaves and Terminalia ch cFebruary 2019 a346-3490 v113 a

Background: Oxidative stress plays an important role in chronic complications of diabetes, cancer, liver disorder etc. The free radicals such as superoxide anions, hydrogen peroxides are causing the oxidative stress and it involves the cellular damage. Evidences recommended that the natural medicines from plant sources are treated to overcome the oxidative stress complications. Objective: The aim of the present is to find the antioxidant activity of the ethanolic extract of Terminalia catappa leaves and Terminalia chebula fruits in the doxorubicin (DOX) induced toxicity rats. Methods: Oxidative stress is induced with a single dose of doxorubicin and then the animals were treated with a dose of various concentration of ethanolic extract of T. catappa leaves and T. chebula fruits (200, 300 mg/kg/b.w) for 21 days. After the treatment, lipid peroxide (LPO), reduced glutathione (GSH), vitamin C, vitamin E, glutathiones- transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase levels are determined. Propranolol 25mg/kg is used as standard drug. Results: In the present study, after the treatment of doxorubicin the levels of SOD, CAT, GSH, GST, GPX, vitamin C, vitamin E levels are decreased and LPO level is increased. After the treatment of T. catappa leaves and T. chebula fruits the levels were returned to the normal level. Conclusion: The results proved that the ethanolic extract of T. catappa leaves and T. chebula fruits may protects the cells from oxidative stress induced by the doxorubicin induced toxicity rats.

10aDoxorubicin10aEnzymatic antioxidant10aNon-enzymatic antioxidant10aOxidative stress10aTermianlia catappa10aTerminalia chebulla.1 aPunniyakotti, Panneerselvam1 aRengarajan, Rengasamy, Lakshminar1 aVelayuthaprabhu, Shanmugam1 aVijayakumar, Kalaiyarasan1 aManikandan, Ramasamy1 aAnand, Arumugam, Vijaya uhttps://www.phcogj.com/article/853