01990nas a2200265 4500008004100000245011300041210006900154260001500223300001200238490000700250520119600257653002101453653001601474653002201490653002201512653001401534653002701548100001801575700002001593700001801613700001901631700001501650700002001665856003901685 2019 eng d00aPhytochemical Analysis, In vitro Antioxidant Capacity and Toxicity Assessment of Copaifera paupera Oleoresin0 aPhytochemical Analysis In vitro Antioxidant Capacity and Toxicit cMarch 2019 a374-3780 v113 a

Introduction: The present study was taken to determine the phytochemical analysis, the antioxidant activity in vitro (FRAP and TBARS methodologies), the oral acute toxicity and antigenotoxicity of the oleoresin Copaifera paupera. Methods: The oleoresin was tested for in vivo cytoprotective capacity using the Micronucleus Test and the Comet Assay in mice bone marrow cells and mice erythrocytes cells, respectively. Results: The oleoresin had low levels of total flavonoids and phenol content and also of antioxidant capacity. Orally, the LD50 appeared to be > 5000 mg/kg (no toxic or low toxic). The results showed all the doses evaluated (180 360, 720 and 1440 mg/kg) antigenotoxic effect by reduce the DNA damage induced by cyclophosphamide, being a 100 % DNA damage reduction at the highest dose evaluated. Conclusion: According to the Micronucleus test, the oleoresin Copaifera paupera had the ability of increase the cell proliferation despite the exposition of cyclophosphamide. (abstract is not arranged properly, improper sentences)

10aAntigenotoxicity10aComet assay10aCopaifera paupera10aMicronucleus test10aOleoresin10aPhytochemical analysis1 aLiviac, Danae1 aRaunelli, Paola1 aAlvis, Rafael1 aPuente, Silvio1 aBest, Ivan1 aReategui, Oscar uhttps://www.phcogj.com/article/840