02448nas a2200205 4500008004100000245012500041210006900166260001800235300001200253490000700265520176000272653002602032653002202058653002402080653002202104653001902126100003002145700002802175856003902203 2019 eng d00aCinnamon species: In vivo Anti-Oxidant Activity of Ethanolic Extracts of Cinnamon Zeylanicum and Cinnamon Cassicae Barks0 aCinnamon species In vivo AntiOxidant Activity of Ethanolic Extra cFebruary 2019 a245-2470 v113 a

Background: The diabetic population is increasing highly in the worldwide due to the poor control of diabetes and environmental conditions. It disturbs the carbohydrate, protein and lipid metabolism. The natural medicines obtained from the plant source may be the effective treatment of diabetes. Objective: The aim of the present study is to investigate the antioxidant activities of the ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae. in streptozotocin (STZ) induced oxidative stress in rats. Methods: Oxidative stress is induced with a single dose of STZ 60 mg/kg b.w. and then the animals are treated with a dose of various concentrations of ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae (200 mg/kg b.w, 400 mg/kg b.w, and 600 mg/ kg b.w) for 45 days. After the treatment lipid peroxides (LPO), reduce glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels are determined. Glibenclamide is used as a standard drug (3 mg/kg b.w.). Results: The present study exposed that the administration of ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae showed a significant decrease in LPO levels. The treatment also finds that the significant increase in GSH, GPx, SOD and CAT levels in the liver, when compared with diabetic control rats. Conclusion: The results proved that the ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae treated group may effectively regulate the antioxidant status in STZ induced diabetic treated groups.

10aAnti-oxidant activity10aCinnamon cassicae10aCinnamon zeylanicum10aDiabetes mellitus10aStreptozotocin1 aPrasanna, Balasubramanian1 aAnand, Arumugam, Vijaya uhttps://www.phcogj.com/article/821