01638nas a2200205 4500008004100000245012700041210006900168260001700237300000800254490000700262520100500269653000901274653001901283653001501302653001001317653001501327100002701342700002401369856003901393 2019 eng d00aOlea europaea and Its Constituents Promote Bone Health by Enhancing Osteoblast Differentiation and Proliferation: A Review0 aOlea europaea and Its Constituents Promote Bone Health by Enhanc cJanuary 2019 a1-70 v113 a

Background: The human bone is in a constant state of balance between bone resorption and bone formation, maintained by the osteoclasts and osteoblasts respectively. Association of Mediterranean diet and bone health has been prevalently studied in recent years. Olive and its constituents have been suggested to be the major contributor to the benefits of the Mediterranean diet in bone health. Method: In this review, cellular and molecular mechanism of bone homeostasis and the influence of olive and its constituents were discussed. Result: Many studies ranging from clinical, animal and in vitro cell culture reported benefits of olive and its constituents in bone health. Olive and its constituent exerted its beneficial effect in bone health through stimulation of bone formation as opposed to inhibition of bone resorption. Conclusion: Olive and its constituents promotes osteoblast differentiation and proliferation.

10aBone10aHydroxytyrosol10aOleuropein10aOlive10aOsteoblast1 aIdrus, Ruszymah, Bt Hj1 aBin Saim, Aminuddin uhttps://www.phcogj.com/article/808