02170nas a2200277 4500008004100000245017700041210006900218260001700287300001000304490000700314520126100321653001301582653001401595653001801609653001901627653000901646100002701655700002001682700002201702700003001724700002001754700001701774700003001791700003201821856003901853 2019 eng d00aEffects of Aqueous and Ethanol Root Extracts of Olax subscopioidea on Inflammatory Parameters in Complete Freund’s Adjuvant-Collagen Type II Induced Arthritic Albino Rats0 aEffects of Aqueous and Ethanol Root Extracts of Olax subscopioid cJanuary 2019 a16-250 v113 a

Aim/Background: Rural and Urban dwellers in Nigeria claim to treat their arthritis with Olax subscorpioidea root extracts. One of the reasons they chose this treatment is that it is effective and cost less than orthodox drugs with their accompanying side effects. Hence the aim of this study is to investigate the anti-arthritis effects of Olax subscorpioidea Afzel ethanol and aqueous root extracts on chicken type II-Complete Freund’s adjuvant (CFA) induced arthritis rat model. Materials and Method: The anti-arthritic potential of ethanol and aqueous root extracts of Olax subscorpioidea was evaluated using the chicken type II-Complete Freund’s adjuvant model in 135 female wistar albino rats. The rats were treated with aqueous and ethanol root extracts of Olax subscorpioidea at varying doses and standard indomethacine drug. Results: The ethanol and aqueous root extracts of Olax subscorpioidea showed significant anti-arthritic activity that was statistically similar to that of indomethacine. Our results suggest that the alcoholic extract of Olax subscorpioidea showed significant (P<0.05) anti-arthritic potential.

10aAdjuvant10aArthritis10aIndomethacine10aPlant extracts10aRats1 aEzeani, Nkiru, Nwamaka1 aIbiam, Udu, Ama1 aOrji, Obasi, Uche1 aIgwenyi, Ikechuku, Okorie1 aAloke, Chinyere1 aAlum, Esther1 aAja, Partrick, Mmaduabuch1 aUgwu, Okechukwu, Paul Chima uhttps://www.phcogj.com/article/803