02176nas a2200265 4500008004100000245013800041210006900179260001700248300001200265490000700277520135300284653001601637653002401653653001301677653001801690653000901708100002301717700002001740700002001760700001701780700002901797700002101826700002401847856003901871 2019 eng d00aPhytochemical Study and Biological Activities of Hydro-Alcoholic Extract of the Leaves of Bridelia ferruginea Benth and its Fractions0 aPhytochemical Study and Biological Activities of HydroAlcoholic  cJanuary 2019 a141-1450 v113 a

Context and purpose: The roots of B. ferruginea are used in traditional Togo medicine in the treatment of diabetes. Studies have shown that leaves have a low antihyperglycemic effect. This study aims to improve the effect of leaves. Methods: The hydroalcoholic extract of the leaves underwent a fractionation (separation in cold alcohol) and an OGTT (Oral Glucose tolerance test) on healthy mice, a phytochemical screening and antioxidant tests (in vitro: DPPH and ex vivo: AAPH) were performed on the extract and its fractions. Results: Phytochemical screening of the extract showed the presence of phenols, flavonoids and condensed tannins as well as the absence of condensed tannins, alkaloids, saponosides and anthracene derivatives. The extract also showed antioxidant activity. The supernatant fraction showed antihyperglycemic activity at 100 mg / kg in the 30th and 60th after glucose administration. Phytochemical screening of the supernatant revealed the presence of phenols, flavonoids and condensed tannins. The supernatant also showed more pronounced antioxidant activity than the total extract. Conclusion: In view of these results, the most active fraction obtained by the separation technique in cold alcohol is the supernatant.

10aAntioxidant10aBridelia ferruginea10aDiabetes10aFractionation10aOGTT1 aBakoma, Batomayena1 aSanvee, Sabrina1 aMetowogo, Kossi1 aPotchoo, Yao1 agadegbeku, Kwashie, Eklu1 aAklikokou, Kodjo1 aGbeassor, Menssanvi uhttps://www.phcogj.com/article/791