02835nas a2200289 4500008004100000245012200041210006900163260001700232300001000249490000700259520191600266653002202182653001502204653001102219653001302230653000902243653003502252100002502287700002602312700002602338700002902364700002702393700003202420700002502452700002902477856003902506 2019 eng d00aAnti-Inflammatory and Neurobehavioral Effects of the Leaves from Maytenus macrocarpa (Ruiz and Pavon) Briquet in Mice0 aAntiInflammatory and Neurobehavioral Effects of the Leaves from  cJanuary 2019 a75-800 v113 a

Context: Maytenus macrocarpa (Chuchuhuasi) has long been employed in Peru as a traditional alternative therapy for several diseases, including cancer, arthritis and diarrhea. Recent studies show that several species of Maytenus have effects on nociceptive and inflammatory signaling, as well as toxic effects on behavioral neuronal pathways. Aims: The aim of this study is to evaluate the anti-inflammatory effects and neurobehavioral side manifestations of the leaf of Maytenus macrocarpa (Ruiz and Pavón) Briquet. Methods and Materials: Experimental study, double blind. 60 male albino mice strain Balb/c were divided in ten groups and each group, was orally feed with different doses of ethanolic extracts of Maytenus macrocarpa (500, 750, 1000, 1250 and 1500 mg/kg), others group received distilled water, caffeine 32 mg/kg, diazepam 32 mg/kg, diclofenac 15 mg/kg and the last group without substance. Neurobehavioral effects were assessed by the Irwin test. The anti-inflammatory activity was measured by the Carrageenan paw oedema test. Statistical analysis was performed with ANOVA test and Fisher exact test. Results: Anti-inflammatory effects of M. macrocarpa were observed in a non-significant trend of dose dependent form. M. macrocarpa displayed an anti-inflammatory effect at 1250 mg/kg and these effects were higher in comparison with diclofenac (74.14% vs 58.62%, one way ANOVA, p<0.05). Neurobehavioral side effects secondary to M. macrocarpa therapy were also identified, these included excitation, abnormal gait, abdominal cramps, piloerection, stereotypes and scratching (Fisher exact, p<0.05, CI 95%). Conclusion: M. macrocarpa leaves presented anti-inflammatory activity and concomitants neurobehavioral side effects.

10aAnti-inflammation10aDiclofenac10aLeaves10aMaytenus10aMice10aNeurobehavioral manifestations1 aElmer, Luján-Carpio1 aHenry, Medina-Salazar1 aAlexander, Mayor-Vega1 aKarola, Medrano-Canchari1 aMaría, Mazuelos-Rivas1 aZaida, Lizarraga-Castañeda1 aCarlos, Pante-Medina1 aAlberto, Salazar-Granara uhttps://www.phcogj.com/article/782