02463nas a2200217 4500008004100000245010700041210006900148260001800217300001400235490000700249520178400256653002102040653002302061653001502084653002202099653001302121100003102134700001602165700002502181856003902206 2018 eng d00aHMG-CoA Reductase Inhibitory Activity of Garcinia latissima Miq. Mesocarp Water Extract for Herbal Tea0 aHMGCoA Reductase Inhibitory Activity of Garcinia latissima Miq M cNovember 2018 as141-s1460 v103 a

Context: High cholesterol in the blood is a risk factor for atherosclerosis that causes various diseases. The main pharmacologic intervention to reduce cholesterol levels is inhibiting the HMG-CoA reductase enzyme. One of the genera of Garcinia, Garcinia dulcis, has potential as an anti-cholesterol. Based on chemotaxonomy, Garcinia latissima Miq. is also estimated to have a potency as anti-cholesterol. Aims: This study aims to test the inhibition of HMG-CoA reductase water extract activity of G. latissima fruit flesh with different duration of infusions. Materials and Methods: Garcinia latissima Miq. mesocarp was extracted using infusion method with different duration of infusions. Each of extracts was tested the inhibitory activity of HMG-CoA reductase as well as the determination of total flavonoid and total phenol content. In addition, the simplicia of the mesocarp of G.latissima Miq. will be made as a herbal tea and a hedonic test is performed to find out the degree of liking for the tea. Result: The test results showed the inhibitory activity of 100 ppm G. latissima Miq. mesocarp water extract with infusion for 5, 10 and 15 min respectively 11.32; 29.02; 13.03%. The 10 min extract with the largest enzyme inhibition had total flavonoids content of 31.24 mg QE / gram extract and total phenol content of 4.64 mg GAE/ gram extract. The result of the hedonic test for the colour, aroma, flavour of herbal tea formula A respectively 30; 30; 20% and formula B respectively for 40; 33.3; 50%. Conclusion: The water extract of G.latissima Miq mesocarp has a low potency in HMG-CoA reductase inhibitory activities.

10aAnti Cholesterol10aGarcinia Latissima10aHerbal Tea10aHMG-CoA reductase10aMesocarp1 aMonalissa, Herra, Williany1 aElya, Berna1 aPuspitasari, Nuraini uhttps://www.phcogj.com/article/766