02516nas a2200229 4500008004100000245012900041210006900170260001800239300001200257490000700269520177200276653002002048653001502068653003202083653001902115653002802134100001802162700001802180700002502198700002402223856003902247 2018 eng d00aPharmacological Evaluation of Bacopa monnieri Extract against Depressive like Behavior Induced by Ethanol Withdrawal in Rats0 aPharmacological Evaluation of Bacopa monnieri Extract against De cNovember 2018 as48-s530 v103 a

Background: Alcohol withdrawal syndrome lead to relapse to alcohol use and depression is the most common symptom of withdrawal. Bacopa monnieri is a traditional memory enhancer and has reported antidepressant properties as well. Objective: The present study was designed to evaluate the protective effects of Bacopa monnieri extract in alcohol withdrawal depressive-like behavior in alcohol-dependent rats. Methods: Plant drug was extracted with ethanol (70% v/v) using soxhlet extraction. Ethanol 7.2%, v/v was given to the rats in a liquid diet for 21 days and then was withdrawn from the diet and animals were observed at 6th and 24th h for withdrawal signs like depressive behavior and locomotor hyperactivity. Results: The phytochemical testing of extract revealed the presence of flavonoids, alkaloids, steroids, and tannins. Bacopa monnieri extract (100, 200 and 300 mg/kg, oral) and fluoxetine (10 mg/kg i.p) treatment at the 6th and 24th h of ethanol withdrawal produced the significant (p<0.001) decrease in the immobility time as compared to the disease control rats when tested on forced swim test and tail suspension test. Bacopa monnieri extract and fluoxetine treatment produced significant (p<0.001) inhibitory effects on locomotor hyperactivity as well. Histopathological examination did not show any remarkable pathological and microscopic changes. Conclusion: Findings from the present study showed that Bacopa monnieri extract treatment has beneficial effects on ethanol withdrawal depressive-like behavior in rats.

10aBacopa monnieri10aDepression10aEthanol withdrawal syndrome10aHistopathology10aLocomotor hyperactivity1 aSharma, Lalit1 aSharma, Aditi1 aGupta, Girdhari, Lal1 aBisht, Gopal, Singh uhttps://www.phcogj.com/article/765