02569nas a2200241 4500008004100000245019200041210006900233260001800302300001200320490000700332520174900339653001802088653002702106653002202133653002802155100000502183700001902188700002002207700002402227700003202251700000502283856003902288 2018 eng d00aPhytochemical Screening, LC-MS Studies and Antidiabetic Potential of Methanol Extracts of Seed Shells of Archidendron bubalinum (Jack) I.C. Nielson (Julang Jaling) from Lampung, Indonesia0 aPhytochemical Screening LCMS Studies and Antidiabetic Potential  cNovember 2018 as77-s820 v103 a

Background: Some Malaysia and Indonesia people believed that root and seed shell of Archidendron bubalinum can treat diabetes. However, seed shell of Archidendron bubalinum has not yet to be scientifically proven and confirmed their ability to treat diabetes. The study of the potential of this seed shell was also scarcely available. Objective: The recent work was aimed to investigate the phytochemical screening of methanol extracts of seed shells of Archidendron bubalinum and to evaluate their chemical compositions and antidiabetic activities. Material and Methods: The methods of phytochemical screening were including alkaloids, flavonoids, tannins, polyphenols, saponins, and terpenoids. Their chemical compositions were determined by Liquid Chromatography-Mass Spectrometry (LC-MS) and antidiabetic activities were performed by α-glucosidase inhibitory method. Results: The phytochemical screening showed that methanol extracts of seed shells of Archidendron bubalinum contain flavonoids, tannins, polyphenols, and terpenoids. This extracts exhibited antidiabetic activity with IC50 7.77 μg/mL. This result was supported by LC-MS analysis which showed the presence of phlorizin and astilbin, in which these compounds had high inhibitory activity against α-glucosidase or diabetes. Conclusion: LC-MS analysis revealed the presence of polyphenol compounds namely phlorizin and astilbin in which had high α-glucosidase inhibitory activity, might largely contribute in the antidiabetic activity. Key words: Phytochemical screening, Mass spectrometry

10aAnti-diabetic10aArchidendron bubalinum10aMass spectrometry10aPhytochemical screening1 a1 aIrawan, Candra1 aRochaeni, Henny1 aSulistiawaty, Lilis1 aRoziafanto, Achmad, Nandang1 a uhttps://www.phcogj.com/article/760