01781nas a2200205 4500008004100000245011300041210006900154260001800223300001200241490000700253520112100260653002601381653002301407653002001430653001601450653002401466100001801490700002801508856003901536 2018 eng d00aNeuroprotective Effects of Valeriana wallichii on Scopolamine Induced Learning and Memory Impairment in Rats0 aNeuroprotective Effects of Valeriana wallichii on Scopolamine In cNovember 2018 as38-s410 v103 a

Objective: Alzheimer’s disease (AD) is the most common cause of dementia in worldwide, treatment options is extremely limited and costly. The present study was conducted to investigate and validate the traditional claim of Valeriana wallichii on scopolamine treated rats as an AD model. Methods: The Valeriana wallichii rhizome ethanol extract (25 mg/kg/day) was administered daily along with scopolamine for a period of 14 days following which the elevated plus maze test were performed to assess learning and memory. Rats treated with scopolamine or vehicle only were also included in the experiment. Result: The study demonstrate that scopolamine treatment resulted in learning and memory deficits which were partially and significantly ameliorated by the Valeriana wallichii rhizome ethanol extract. Conclusion: The study demonstrates the ability of the Valeriana wallichii rhizome ethanol extract to reverse scopolamine-induced learning and memory deficits in rats.

10aAlzheimer’s disease10aElevated Plus Maze10aNeuroprotective10aScopolamine10aValeriana wallichii1 aPathan, Aslam1 aAlshahrani, Abdulrahman uhttps://www.phcogj.com/article/754