02103nas a2200229 4500008004100000245012100041210006900162260001600231300001400247490000700261520135800268653001401626653002201640653001701662653001701679653002101696100003401717700002801751700003801779700001701817856003901834 2018 eng d00aEffect of Trigonella foenum gracecum (fenugreek) Seed Extract in Experimentally Induced Gastric Ulcer in Wistar Rats0 aEffect of Trigonella foenum gracecum fenugreek Seed Extract in E cAugust 2018 a1169-11730 v103 a

Background: Trigonella foenum graceum (Fenugreek) seeds are commonly used in India as traditional medicine for Diabetes, Dysmenorrhea, lactation and arthritis. The gastro-protective role of Fenugreek seeds are yet to be explored. Objectives: To evaluate the effect of Fenugreek seed extract in Indomethacin induced gastric ulcer models. Materials and Methods: Albino wistar rats were divided into five groups with eight animals in each. Gastric ulcer was induced using Indomethacin 20 mg/Kg. Fenugreek at dose of 200mg/Kg and 400mg/Kg was administered to group III, IV and group V received Rantidine 30mg/Kg. Ulcer index, volume of gastric juice and acidity was estimated. To study the anti-oxidant property the level of catalase, SOD, GST and T. Bars were done. Results: Fenugreek treated group III showed a significant decrease in ulcer index, volume of gastric juice and acidity when compared to control positive group II. Oxidative enzyme study indicated a significant increase in Catalase, SOD and GSH value in treated group when compared with control positive group II and significant decrease in T. Bars value in treated group. Conclusion: Fenugreek seed extract has both gastro-protective and Anti-oxidant property.

10aFenugreek10aGastro-protection10aIndomethacin10aseed-extract10aUlcer inhibition1 asingaravelu, shreelakshmidevi1 aSankarapillai, Jaikumar1 aChandrakumari, Abilash, Sasidaran1 aSinha, Pammy uhttps://www.phcogj.com/article/735