02326nas a2200205 4500008004100000245013800041210006900179260001600248300001400264490000700278520163400285653001901919653001801938653003101956653002601987653001802013100002802031700002202059856003902081 2018 eng d00aAntithrombotic Effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. on Collagen-epinephrine Induced Thromboembolism In Mice0 aAntithrombotic Effect of Kaempferia galanga L and Curcuma xantho cAugust 2018 a1149-11530 v103 a

Objective: Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. have been proven to possess antiplatelet activity in vitro. The aim of this study is to investigate the antithrombotic effect of the rhizome extracts of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb in a mouse thrombotic model. Methods: The ethanol extracts of K. galanga and C. xanthorrhiza were orally administered with three different doses (7, 14 and 28 mg/20 g BW) in two experimental mouse models. Bleeding time prolongation was observed on mice tail that had been cut and the survival rate of mice was observed after thromboembolism induction by collagenepinephrine. These two experiments were observed after 7 days extracts pre-treatment and compared to the positive control, aspirin. Results: A potent effect of K. galanga and C. xanthorrhiza extracts were demonstrated through significant bleeding time prolongation compared to control group. C. xanthorrhiza extract exhibited better activity than K. galanga extract. Moreover, both K. galanga and C. xanthorrhiza extracts significantly protected mice from thromboembolic death, where the protective effect of C. xanthorrhiza extract was stronger than K. galanga extract in a dose-dependent manner. Conclusion: K. galanga and C. xanthorrhiza extracts have a potential to be developed as antithrombotic agents against platelet thromboembolism.

10aAntithrombotic10aBleeding time10aCurcuma xanthorrhiza Roxb.10aKaempferia galanga L.10aSurvival rate1 aSaputri, Fadlina, Chany1 aAvatara, Chavella uhttps://www.phcogj.com/article/734