02145nas a2200253 4500008004100000245009500041210006900136260001600205300001400221490000700235520141400242653002101656653001301677653001101690653001201701653002301713653000801736100002501744700001901769700002101788700001601809700002701825856003901852 2018 eng d00aCholesterol-lowering Effects of Extract from Garcinia daedalanthera in Hyperlipidemic rats0 aCholesterollowering Effects of Extract from Garcinia daedalanthe cAugust 2018 a1125-11280 v103 a

Background: A native plant from Indonesia, Garcinia daedalanthera has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that Garcinia daedalanthera can modulate the lipid profiles of hyperlipidemic rats. Objective: This study aimed to evaluate the antihyperlipidemic potential of Garcinia daedalanthera extract. Materials and Methods: Garcinia daedalanthera leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. Results: The results showed that Garcinia daedalanthera extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. Conclusion: This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of Garcinia daedalanthera extract which serves as a new potential natural product for preventing hyperlipidemia.

10aAnti-cholesterol10aGarcinia10aHerbal10aIn vivo10aPre-clinical study10aRat1 aNajib, Sarah, Zielda1 aFachri, Wilzar1 aSauriasari, Rani1 aElya, Berna1 aTjandrawinata, Raymond uhttps://www.phcogj.com/article/727