02264nas a2200241 4500008004100000245010800041210006900149260001600218300001400234490000700248520154100255653001601796653001301812653001401825653002201839653002601861100001901887700001601906700002101922700002101943700001901964856003901983 2018 eng d00aArginase Inhibitory, Antioxidant Activity and Pharmacognosy Study of Sterculia macrophylla Vent. Leaves0 aArginase Inhibitory Antioxidant Activity and Pharmacognosy Study cAugust 2018 a1109-11130 v103 a

Objective: The purpose of this study was to investigate the arginase inhibitory activity, antioxidant activity, and also pharmacognostical study of Sterculia macrophylla leaves. The main component of genus Sterculia was flavonoid that was well known to demonstrate arginase inhibitory activity. Methods: Sample was extracted gradually using n-hexane, ethyl acetate, and methanol solvents, subsequently. The n-hexane, ethyl acetate, and methanol extract were determined for their arginase inhibitory activity. The most active extract was methanol extract. This extract was determined for its antioxidant activity, arginase inhibitory activity, identification of chemical compound, chromatogram profile and determined the content of total flavonoid. The leaves and powder of Sterculia macrophylla were identified with microscopic and macroscopic evaluation. Results: The most active extract was methanol extract with IC50 114,659 μg/mL for arginase inhibitory activity and IC50 78.47 μg/mL for DPPH scavenging activity. The secondary metabolite of methanol extract presence compound of alkaloid, flavonoid, tannin, terpene, and glycoside. The total flavonoid content was 141.10 mg/gram extract. The star-shape trichoma was identified as a specific fragment. Conclusion: The methanol extract of Sterculia macrophylla showed activity as arginase inhibitor and antioxidant.

10aAntioxidant10aArginase10aFlavonoid10aPharmacognostical10aSterculia macrophylla1 aPrastiwi, Rini1 aElya, Berna1 aSauriasari, Rani1 aHanafi, Muhammad1 aDesmiaty, Yesi uhttps://www.phcogj.com/article/715