01997nas a2200229 4500008004100000245009300041210006900134260001600203300001400219490000700233520127500240653002801515653002201543653001301565653002101578653001301599653003401612100003001646700002501676700002701701856003901728 2018 eng d00aFormulation and Evaluation of Solid Dispersion Tablet of Andrographis paniculata Extract0 aFormulation and Evaluation of Solid Dispersion Tablet of Androgr cAugust 2018 a1047-10540 v103 a

Objective: To enhance solubility of ethanolic extract of Andrographis paniculata by solid dispersion technique and to perform formulation and evaluation of solid dispersion tablet. Materials and Methods: Solid dispersion of Andrographis paniculata extract has been prepared by solvent evaporation technique using soluplus and PEG 6000. Prepared solid dispersions have been evaluated for various micromeritic properties. The tablets of solid dispersion were prepared by direct compression technique and were evaluated for various physical tests and in-vitro dissolution study. Results: The study showed that prepared solid dispersion has good flow property and compressibility. The solubility of extract was found to be more from solid dispersion prepared by using soluplus than that of prepared by using PEG 6000. The rate of drug release was found to be higher in acidic buffer at pH 1.2 as compared to that of in phosphate buffer at pH 6.8. Conclusion: The study concludes that the solid dispersion tablet of ethanolic extract of Andrographis paniculata can be effectively prepared using soluplus by solvent evaporation techniqu

10aAndrographis paniculata10aEthanolic extract10aPEG 600010aSolid dispersion10aSoluplus10aSolvent evaporation technique1 aNitave, Sachin, Annasaheb1 aChougule, Nilesh, B.1 aKoumaravelou, Kailasam uhttps://www.phcogj.com/article/714