01826nas a2200217 4500008004100000245006600041210006500107260001600172300001200188490000700200520122900207653001601436653001501452653001001467653001501477653001701492100001801509700002301527700001901550856003901569 2018 eng d00aAntiurolithiatic Activity of Daucus carota: An In vitro Study0 aAntiurolithiatic Activity of Daucus carota An In vitro Study cAugust 2018 a880-8840 v103 a

Context: Urolithiasis is a polygenic disorder with complex etiology and even complicated treatment outcomes. Daucus carota is a widely cultivated crop with traditional claims for its antiurolithiatic potential. Aim: Present study was an attempt to investigate the antilithic potential of D. carota root extract (DCRE) against calcium oxalate (CaOx) urolithiasis by employing in vitro methods. Methods: Nucleation, growth and aggregation assay of CaOx crystallization were used. FT-IR analysis was used for characterizing CaOx crystals. Results: DCRE exhibited significant inhibition of nucleation, growth and aggregation of CaOx crystals. It produced a favorable morphological transformation of CaOx crystals from calcium oxalate monohydrate to calcium oxalate dihydrate. FT-IR analysis confirmed formation of calcium oxalate monohydrate crystals to be utilized for growth and aggregation assays. Conclusion: DCRE possesses significant antiurolithiatic activity against CaOx urolithiasis in vitro which could be attributed to its saponins, tannins, flavonoids and polyphenolic content.

10aAggregation10aFlavonoids10aFT-IR10aNucleation10aUrolithiasis1 aBawari, Sweta1 aSah, Archana, Negi1 aTewari, Devesh uhttps://www.phcogj.com/article/701