02109nas a2200241 4500008004100000245018000041210006900221260001600290300001200306490000700318520128200325653002501607653002301632653002501655653002101680653002101701100002301722700001601745700002101761700001801782700002801800856003901828 2018 eng d00aIdentification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C0 aIdentification by Docking Simulation and in vivo Effect of Essen cAugust 2018 a875-8790 v103 a

Aim: This study examines the effect of inhalation of essential oil of cinnamon (Cinnamomum burmannii) on the metabolic activity of hormone receptors olfactory system of mice Balb C. Methodology: Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. Result: The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from Cinnamommum burmannii and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.

10aCinnamomum burmannii10adocking simulation10aimmunohistochemistry10aleptin receptors10aolfactory system1 aKusmardi, Kusmardi1 aTedjo, Aryo1 aFadilah, Fadilah1 aArsianti, Ade1 aParamita, Rafika, Indah uhttps://www.phcogj.com/article/700