02635nas a2200205 4500008004100000245012900041210006900170260001600239300001200255490000700267520194800274653001902222653002702241653001702268653002902285653002802314100002202342700002602364856003902390 2018 eng d00aAntioxidant Activities, Acute Toxicity and Chemical Profiling of Torch Ginger (Etlingera elatior Jack.) Inflorescent Extract0 aAntioxidant Activities Acute Toxicity and Chemical Profiling of  cAugust 2018 a979-9820 v103 a

Aim/Background: The objectives of the study were to determine total phenolic contents, flavonoid contents, antioxidant activities and assess acute toxicity of torch ginger (Etlingera elatior Jack.) inflorescent hydroethanolic extract. Methods: The analysis of total phenolic contents, total flavonoid contents and antioxidant activities were analyzed spectrophotometrically using micro-titer plate reader. With regard to acute toxicity assessment, Wistar rats were fed with a single dose of torch-ginger either 1.0, 1.5 or 2.0 g extract/kg body weight in comparison with control group. Results: Total phenolic contents, flavonoid contents of the extract were 0.17±0.02 mM gallic acid equivalent/g extract and 0.30±0.01 mM quercetin equivalent/g extract, respectively. The antioxidant evaluation using DPPH radical scavenging assay, FRAP assay and ABTS radical scavenging assay were 0.14±0.08 mg/ml (EC50), 0.13±0.01 mmol Fe2+ equivalent/g extract and 0.30±0.12 mM trolox equivalent/g extract, respectively. According to acute toxicity, no mortality or bizarre behavior had been observed throughout 14 days. Clinical chemistry including blood glucose, AST, ALT, BUN, creatinine, total cholesterol, triglyceride, HDL, LDL, total serum protein, albumin, globulin and total bilirubin were in normal ranges and comparable to the control (p<0.05). In conclusion, phenolic compounds and flavonoids of torch-ginger could be measured and indicated the quality of the extract as well as antioxidant activities. Regarding acute toxicity assessment, the extract was safe for experimental animals up to 2.0 g extract/kg body weight. Conclusion: Torch-ginger extract exhibited high amounts of phenolic contents, flavonoid contents, antioxidant activities and was safe in animal model.

10aAcute toxicity10aAntioxidant Activities10aTorch ginger10aTotal flavonoid contents10aTotal Phenolic Contents1 aSungthong, Bunleu1 aSrichaikul, Buavaroon uhttps://www.phcogj.com/article/696