02083nas a2200181 4500008004100000245017900041210006900220260001400289300001000303490000700313520143600320100002301756700001601779700002101795700001801816700002801834856003901862 2018 eng d00aIdentification by Docking Simulation And In Vivo Effect of Essential Oil From Cinnamommum Burmannii as Antiobesity With Leptin Receptor In The Olfactory System of Mice Balb C0 aIdentification by Docking Simulation And In Vivo Effect of Essen cJuly/2018 a73-770 v103 a

Aim: This study examines the effect of inhalation of essential oil of cinnamon (Cinnamomum burmannii) on the metabolic activity of hormone receptors olfactory system of mice balb C. Methodology: Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. Result: The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from Cinnamommum burmannii and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.

Keywords: olfactory system, leptin receptors, Cinnamomum burmannii, docking simulation, immunohistochemistry

1 aKusmardi, Kusmardi1 aTedjo, Aryo1 aFadilah, Fadilah1 aArsianti, Ade1 aParamita, Rafika, Indah uhttps://www.phcogj.com/article/669