01867nas a2200229 4500008004100000245011700041210006900158260001400227300001200241490000700253520115300260653002601413653002101439653001601460653001701476653001201493100003201505700001901537700002601556700002001582856003501602 2018 eng d00aAnti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats0 aAntiInflammatory Antipyretic and Acute Toxicity Effects of nButa cJune 2018 a763-7670 v103 a

Objectives: This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. Flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer’s yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 μL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. Flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer’s yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.

10aAtractylis flava desf10aBrewer’s yeast10aEgg albumin10aInflammation10aPyrexia1 aAkram, Melakhessou, Mohamed1 aNaima, Benkiki1 aEddine, Marref, Salah1 aSoumia, Bouzidi uhttp://fulltxt.org/article/666