02037nas a2200217 4500008004100000245011000041210006900151260001400220300001200234490000700246520135200253653002201605653002001627653001801647653002201665100002601687700001901713700003201732700002001764856003501784 2018 eng d00aAcute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats0 aAcute Toxicity Antiulcer and Antiinflammatory Effects of Methano cJune 2018 a758-7620 v103 a

Objectives: To evaluate the in vivo anti-ulcer and anti-inflammatory activities of methanol extract of the aerial parts of Gladiolus segetum. Methods: First methanol extract of Gladiolus segetum was subjected to the acute oral toxicity test according to the OECD, guideline no 423.The anti-ulcer activity of Gladiolus segetum was investigated by ethanol induced gastric ulcer in Wistar rats. Methanol extract was administered by gavage one hour before ethanol to the different groups at a dose corresponding of 100,250 and 500 mg/kg body weight. The control group received normal saline in comparable volume (10ml/kg body weight) by the same route. The anti-inflammatory activity of the tested extract was evaluated in adult wistar rats by the egg albumin induced paw edema method. Results: A significant reduction (p <0.001) was observed in the results of the present study, revealed that methanol extract possessed gastroprotective activity and exerts a topical anti-inflammatory effect in vivo. Conclusion: These results suggest that methanol extract of Gladiolus segetum may represent an important clinical alternative in anti-inflammatory and antiulcer genic therapeutics.

10aAnti-inflammatory10aAntiulcer genic10aGastric ulcer10aGladiolus segetum1 aMarref, Salah, Eddine1 aBenkiki, Naima1 aMelakhessou, Mohamed, Akram1 aBouzidi, Soumia uhttp://fulltxt.org/article/665