02301nas a2200229 4500008004100000245009200041210006900133260001400202300001200216490000700228520162600235653001401861653001301875653002301888653000801911653001701919653002501936100002701961700003001988700001802018856003502036 2018 eng d00aProtective Effect of Dietary Curcumin and Capsaicin on LPS-Induced Inflammation in Mice0 aProtective Effect of Dietary Curcumin and Capsaicin on LPSInduce cJune 2018 a725-7290 v103 a

Objective: The current study aimed to evaluate the anti-inflammatory potency of combined curcumin and capsaicin against lipopolysaccharide (LPS) induced organ damage in mice. Methods: Adult male albino mice were distributed into five experimental groups for treatment with olive oil, LPS, curcumin, capsaicin and their combination, respectively, for 7 days prior to LPS induced inflammation. At the end of the experiment, blood samples were collected and used for the analysis of serum non-specific enzymes including serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin (TB), urea, creatinine and sugar, while the organ homogenates were subjected for the evaluation of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutothione S transferase (GST), nitric oxide (NO); lipid peroxidation (LPO) and it was further confirmed by histopathological study of different organs. Results and Conclusion: Curcumin, capsaicin and their combination had shown significant restoration of non-specific serum enzymes, antioxidant enzymes and attenuated inflammatory cells infiltration thereby preventing tissue/organ damage in LPS-challenged mice. However, the protective effect was found to be more when the two compounds were fed in combination. This beneficial potency of combined spice treatment is may be due to the contribution of diversified active moieties of curcumin and capsaicin in combination compared to individual molecules.

10aCapsaicin10aCurcumin10aLipid peroxidation10aLPS10aSeptic shock10aSuperoxide dismutase1 aVasanthkumar, Thriveni1 aHanumanthappa, Manjunatha1 aBT, Prabhakar uhttp://fulltxt.org/article/659