02562nas a2200229 4500008004100000245013500041210006900176260001500245300001200260490000700272520183600279653001702115653002602132653003302158653002102191653001602212100001802228700001702246700001702263700001702280856003502297 2018 eng d00aExtraction of Total Phenolics, Flavonoids and Tannins from Paederia foetida L. Leaves and their Relation with Antioxidant Activity0 aExtraction of Total Phenolics Flavonoids and Tannins from Paeder cMarch 2018 a541-5470 v103 a

Introduction: Paederia foetida L. is a climbing shrub that possesses several ethnomedicinal uses with immense pharmacologic relevance. Objective: The study aims to determine an efficient extraction condition for phenolic compounds with substantial antioxidant activity. Materials and Methods: Solvent (aqueous, methanol, ethanol and acetone) extracts were made from fresh leaves (FL) and shade dried leaves (SDL) of P. foetida with different durations (12, 24, 36 and 48 h). Quantitative estimations of all extracts were made for total phenolic content (TPC), total flavonoid content (TFC) and total tannin content (TTC) along with their total antioxidant activity (TAA). The phenolic contents of different extracts were correlated with their TAA. Extracts with highest phenolic yield and TAA estimates for each solvent were assessed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2ˊ-azinobis-3-ethylbenzthiazoline-6- sulfonic acid (ABTS), superoxide (SO) and ferric reducing antioxidant power (FRAP) assays. Results: Methanol exhibited the highest extraction ability for TPC, TFC and TAA while aqueous extractions are superior for TTC. The maximum estimates of all the studied components are noted at 48 h. Mostly, extracts of SDL are superior to FL. TPC and TFC are interrelated between themselves as well as showed positive and significant correlation with TAA. The antioxidant assays (DPPH, ABTS, SO and FRAP) reveal higher antioxidant activity with methanolic extracts compared to other studied solvents. Conclusion: The study highlights antioxidant properties of phenolics, particularly flavonoids in P. foetida, which can be further explored for its pharmacological importance.

10aAntioxidants10aExtraction conditions10aFresh and shade dried leaves10aPaederia foetida10aPolyphenols1 aOjha, Shaswat1 aRaj, Adarsha1 aRoy, Alokesh1 aRoy, Sudipta uhttp://fulltxt.org/article/521