02380nas a2200253 4500008004100000245016300041210006900204260001500273300001200288490000700300520154100307653002201848653001201870653002201882653001301904653001801917100002801935700002801963700002501991700002102016700002902037700002502066856003502091 2018 eng d00aEffect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)0 aEffect of Gynura procumbens Extracts on AntiProliferative Activi cMarch 2018 a492-4960 v103 a

Objective: Gynura procumbens (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of Gynura procumbens on U-87 cell line, human Glioblastoma multiforme cell line. Methods: In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. Results: The ethanol and methanol extracts of Gynura procumbens was found to have high anti-proliferative effect on U-87 cell line with IC50 less than 20μg/ml. By comparing IC50 value, ethanol and methanol extracts of Gynura procumbens had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. Conclusion: To the best of our knowledge, this is the first study of exploring the effect of Gynura procumbens extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human Glioblastoma multiforme cells.

10aAntiproliferative10aEthanol10aGynura procumbens10aMethanol10aU87 cell line1 aRohin, Mohd, Adzim Khal1 aJumli, Mimie, Noratiqah1 aRidzwan, Norhaslinda1 aBaig, Atif, Amin1 aLatif, Ahmad, Zubaidi Ab1 aHadi, Norhayati, Abd uhttp://fulltxt.org/article/514