02326nas a2200253 4500008004100000245015400041210006900195260001200264300001200276490000600288520150600294653001301800653001201813653003001825653002801855653003101883653002901914100001601943700001601959700001901975700001901994700002102013856003802034 2015 eng d00aDynamic Comparison of Free Radical Scavenging Abilities of Hypericum Perforatum L., Herba Verbenae Officinalis, and Valeriana Officinalis L. Extracts0 aDynamic Comparison of Free Radical Scavenging Abilities of Hyper c01/2015 a198-2040 v73 a

Objectives: The purpose of this research was to compare the dynamic antioxidant activities and the free radical scavenging abilities of three botanical supplements, Hypericum perforatum L. (HPL), Herba Verbena Officinalis (HVO), and Valeriana officinalis L. (VO), which have been reported to effectively treat menopause symptoms. Methods: The antioxidant activities of the three supplements were determined by the ferric reducing ability of plasma (FRAP) assay. In addition, their free radical scavenging abilities were studied by ftheir interactions with the stable radicals of 2, 2’-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). Results: The results indicated that the HPL ethanolic extract exhibited greater antioxidant activity (1.2688 ± 0.01 mmol Trolox/g) than the HVO ethanolic extract (1.1686± 0.043 mmol Trolox/g) and the VO ethanolic extract (0.2579 ± 0.0031 mmol Trolox/g) as compared to Nilestriol (0.0026±0.0012), a positive control agent in the experiment. Moreover, the HPL extract showed remarkable free radical scavenging activity against ABTS+, and the HVO extract was the most potent against DPPH. Conclusion: These activities may be attributed to the total flavonoid or phenolic acid contents of among these extracts.

10aABTS•+10aDPPH•10aHerba Verbena Officinalis10aHypericum perforatum L.10aMenopause Oxidative Stress10aValeriana officinalis L.1 aLi, Yi-ming1 aLiu, Yan-Ru1 aXiao, Bing-Kun1 aYang, Jian-Yun1 aHuang, Rong-Qing uhttps://www.phcogj.com/article/57