02464nas a2200253 4500008004100000245017200041210006900213260001700282300001200299490000700311520162500318653002201943653002201965653002001987653001402007100001602021700001602037700002502053700002402078700001602102700002702118700003002145856003502175 2018 eng d00aEvaluation of Chemoprotective Effect of Quercetin from Argyreia speciosa against N-methyl-N-Nitro-N-Nitrosoguanidine and NaCl-Induced Gastric Carcinomas in Wistar Rats0 aEvaluation of Chemoprotective Effect of Quercetin from Argyreia  cJanuary 2018 a215-2200 v103 a

Objectives: This study was carried out to investigate the chemo protective potential of Quercetin, an isolated compound from Argyreia speciosa, on N-methyl-N-nitro-N-nitrosoguanidine and NaCl-induced gastric carcinomas in Wistar rats. Methods: The rats were fed with a diet supplemented with 8% NaCl and simultaneously given N-methyl-N-nitro-N-nitrosoguanidine. After administration of the carcinogen, quercetin was administered. The whole stomach and a part of duodenum were sampled, cut open and tumors were recorded. The specimens were histopathologically investigated and the expression of surviving was examined with immunohistochemical analysis. Results and Conclusions: The treatment with quercetin significantly increases body weight in the rats after N-methyl-N-nitro-N-nitrosoguanidine administration. Survivin expression in glandular stomachs of normal rats, of rats in adenocarcinomas and quercetin at dose dependent manner treated rats were 0%, 90%, 75%, 33.3-25%, respectively. Compared with the survivin expression in negative rats, the differences were significant. Compared with the survivin expression in normal rats, the differences were significant. Histological observations of stomach tissues too correlated with the biochemical observations. These findings indicated that the Quercetin treatment could stimulate immunity activity in rats with N-methyl-N-nitro-N-nitrosoguanidine induced gastric carcinoma and have pronounced effect on survivin which is an attractive target for gastric cancer therapy.

10aArgyreia speciosa10aGastric carcinoma10aImmunochemistry10aQuercetin1 aAzmi, Lubna1 aShukla, Ila1 aGupta, Shyam, Sundar1 aChaudhary, Aniruddh1 aKant, Padam1 aYadav, Narayan, Prasad1 aRao, Chandana, Venkateswa uhttp://fulltxt.org/article/467