02743nas a2200241 4500008004100000245011900041210006900160260001800229300001200247490000700259520197700266653002302243653001002266653001502276653002402291653002502315100003002340700001902370700002402389700002602413700002702439856003502466 2018 eng d00aGC-MS Analysis of Phytochemical Compounds in Syzygium polyanthum Leaves Extracted using Ultrasound-Assisted Method0 aGCMS Analysis of Phytochemical Compounds in Syzygium polyanthum  cDecember 2017 a110-1190 v103 a

Context: Syzygium polyanthum has been traditionally formulated by the folklore for the treatment of diseases including diarrhea, rheumatism, diabetes mellitus, hypercholesterolemia, hypertension, gastritis and hyperuricemia. Normally, its phytochemicals are always extracted using solvent, maceration and steam distillation methods, but the use of ultrasound-assisted extraction (UAE) method is still not well documented. Aims: This study aims to extract the phytochemical compounds present in S. polyanthum leaves using UAE and to identify them by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Methodology: The leaves were consecutively soaked with n-hexane, ethyl acetate and methanol in a bath sonicator to derive n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) extracts of S. polyanthum leaves and then the extracts were subjected to GC-MS analysis. Mass-spectral databases of peaks were compared with database from Wiley, NIST and FNSCC libraries for compound identification. Results: GC-MS analyses of HSP, EASP and MSP showed the presence of 21, 27, and 31 peaks, respectively. The major compound for HSP (31.912%), EASP (27.042%), and MSP (22.386%) were unknown compounds which were detected at retention time between 61.980 and 62.29 min, thus requires further characterization. Squalene and phytol were among the other major compounds present in all three extracts. Several identified compounds in the extracts such as squalene, phytol, hentriacontane, palmitic acid, α-pinene, nerolidol, linalool, α-tocopherol and β-tocopherol were known bioactive compounds. Conclusion: GC-MS analyses of n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) of S. polyanthum leaves extracts have revealed the presence of some known bioactive compounds with therapeutic importance.

10aBioactive compound10aGC-MS10aSonication10aSyzygium polyanthum10aUltra-sound-assisted1 aRahim, Erlena, Nor Asmira1 aIsmail, Azlini1 aOmar, Muhammad, Nor1 aRahmat, Umi, Nadhirah1 aAhmad, Wan, Amir Nizam uhttp://fulltxt.org/article/406