02445nas a2200217 4500008004100000245013700041210006900178260001200247300001200259490000600271520171500277100002801992700003202020700002202052700002302074700002802097700002602125700001902151700001902170856003802189 2015 eng d00aEffectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism0 aEffectiveness of Sidr Honey on the prevention of ethanolinduced  c01/2015 a157-1640 v73 a

Background: Sider (Ziziphus spina-christi (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. Aim of the study: The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. Materials and methods: Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95% ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). Conclusion: Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.

1 aTaha, Manal, Mohamed El1 aAbdelwahab, Siddig, Ibrahim1 aElsanousi, Rashad1 aSheikh, Bassem, Y.1 aAbdulla, Mahmood, Ameen1 aBabiker, Saif, Eldeen1 aElraih, Husham1 aMohamed, Eldaw uhttps://www.phcogj.com/article/46